Dental Education
Online Dental Education Dental education lectures and videos Online dental ce Dental education articles Expert dental educators Dental products education Dental Community
 
Video Details
PRGF— Plasma Rich in Growth Factors: A Simple Solution for Implant & Regenerative Surgery - Part 1 of 2

Description:
Immediate gratification finds new meaning for the “Baby Boomer” population—those 50+ year-olds who lead busy lives and careers and demand service, luxury, and immediate load implants. This is the same group who wishes to retain their youth and in whom the hands of the healing clock are slowed. Today, the challenge of satisfying their needs and wants becomes simplified with the use of plasma rich in growth factors (PRGF), a gel-like substance prepared from two to four 5-cc vials of the patient’s own blood that have been subjected to a 8-minute centrifugation cycle at 460g, then meticulously pipetted into plasma fractions that contain the growth factors targeted for regeneration of both hard and soft tissue (Figure 1). Of the growth factors (GFs) most abundant in PRGF are 3 whose actions most significantly affect this regenerative process. PDGF increases the proliferation of osteoblasts in vitro; TGF- in specific doses boosts type I and type IV collagen-derived protein synthesis as well as increases mineralization of the bone matrix, favoring implant anchorage. Insulin-like growth factor-I (IGF-I) stimulates bone formation, inducing cellular proliferation, differentiation, and biosynthesis of type I collagen in addition to its mitogenic effect on multinucleated osteoclastic cells.1 More importantly, the unique combination of GFs produced with this protocol works synergistically. PRGF differentiates itself from other platelet-rich plasmas (PRPs) because it intentionally excludes inflammatory leukocytes; moreover, PRGF’s activation with calcium chloride alone forbids the use of thrombin because it shocks platelets. (The use of bovine thrombin is prohibited in Europe.2) Instead, the PRGF activation protocol yields a gradual-release kinetics for precious healing proteins stored in the alpha-granules. Current treatment protocols recommend a routine 6-12 month course of healing; this requirement increases the risk of reabsorption of the alveolar process and loss of crestal height and width that, in some cases, can delay, jeopardize, or even preclude implant placement. Others work reasonably well on soft tissue regeneration but fail with bone regeneration.4,5 Intervention with PRGF in the same surgery as the extraction can derail the physiological inevitability of further crestal bone loss and improve the quality and quantity of bone regenerated. Such a scenario is possible thanks to the PRGF technique, which dramatically hastens the healing process in post-extraction sites, as well as grafting for peri-apical lesions, 3-wall defects, large craters around teeth, gingival recession and, in some cases, can enable immediate implant placement which would have been delayed otherwise.6-10 Another favorable clinical observation is that over 10 years in 5,000 post-extraction sites filled with PRGF in this practice, there has not been even one incident of alveolitis (dry socket).

Date Added:
10/28/2013

Author(s):

Eduardo Anitua, MD, DDS, PhD Eduardo Anitua, MD, DDS, PhD
Eduardo Anitua received M.D. in medicine and surgery at the University of Salamanca. He is specialist in Stomatology by the University of the Basque Country (Bilbao, Spain), c...
[read more]


Featured Products
B.T.I. Biotechnology Institute
PRGF Endoret



Questions & Comments
ismail salejee - (12/8/2013 7:24 AM)

DR ANITUA thank you, with deep appreciation , for your excellent and comprehensive review for the groundbreaking use of prgf for dental and medical applications.Moreover , the dental community is indebted for your many years of pioneering work to develop this concept to its current level.I am keenly awaiting part 2!Once again,your efforts are noted and valued . ismail south africa

Related Videos
Ridge Preservation and Augmentation In Immediate Implant Therapy Part 2 Premium Member Content

Ridge Preservation and Augmentation In Immediate Implant Therapy Part 2
Dr. Horowitz utilizes clinical cases and research to outline successful approaches to extraction site enhancement and implant placement.

Presented By: Robert A. Horowitz, DDS
Presentation Style: Lecture
Community Rating:
 
Watch Now>>
Incisor Implant in Narrow Ridge with BMP-2 Infuse and CT Graft Premium Member Content

Incisor Implant in Narrow Ridge with BMP-2 Infuse and CT Graft
Dr. Paul Kozy shares an approach to the routine clinical challenge of placing an implant in a narrow ridge.

Presented By: Paul S Kozy, DDS
Presentation Style: Video
Community Rating:
 
Watch Now>>
Chin Bone Block Augmentation	Premium Member Content

Chin Bone Block Augmentation
3D CT Technology & Piezosurgical Techniques

Presented By: Maurice Salama, DMD
Presentation Style: Video
Community Rating:
 
Watch Now>>
Related Courses
Biologic Strategies to Enhance Clinical and Aesthetic Success in Oral Implantology Premium Member Content

Biologic Strategies to Enhance Clinical and Aesthetic Success in Oral Implantology
This webinar will discuss clinical strategies for treatment of the complex implant site involving bone grafting and implant placement. Our understanding of cellular pathways, and our ability to control the wound response, expands our capacity to effect better aesthetic outcomes and compress treatment time. The reduction of the inflammatory phase of tissue regeneration speeds up osseointegration, prevents crestal bone loss, maintains papillary form, increases the density of peri-implant bone and increases tissue biotype. This enhanced tissue response allows us to predictably treat even the most complex surgical cases, compress time to final reconstruction, and to maintain these favorable tissue outcomes over an extended period of time. The use of dental implants with advanced biologic features and the incorporation autologous growth factors will be demonstrated.

Presented By: Robert J. Miller, DDS, FACD, DABOI
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Credit)
Watch Now>>
Osseointegration & Augmentation Premium Member Content

Osseointegration & Augmentation
A 4 part course worth 1 CEU.

Presented By: Maurice Salama, DMD;Ziv Mazor, DMD;Hom-Lay Wang, DDS, MSD, PhD;Ady Palti, DDS
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
Bone Augmentation & Bioengineering in the Clinical Implant Practice Premium Member Content

Bone Augmentation & Bioengineering in the Clinical Implant Practice
This webinar will introduce efficient and predictable bone graft solutions as well as bioactive modifiers that can be immediately incorporated into clinical practice.

Presented By: Maurice Salama, DMD
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
Related Articles
Minimally Invasive Alveolar Ridge Augmentation Procedure (Tunneling Technique) Using rhPDGF-BB in Combination with Three Matrices: A Case Series

Minimally Invasive Alveolar Ridge Augmentation Procedure (Tunneling Technique) Using rhPDGF-BB in Combination with Three Matrices: A Case Series
This study investigated a minimally invasive surgical procedure for alveolar ridge augmentation that combined recombinant human platelet-derived growth factor BB (rhPDGF-BB) and three different matrices.

Author(s): Myron Nevins, DDS;Marc L. Nevins, DMD, MMSc; Marcelo Camelo, DDS; Peter Schupbach, PhD; Bernard Friedland, BChD, MSc, JD; Joao Marcelo Borges Camelo, DDS; David M. Kim, DDS, DMSc
View Article>>
Multitier Technique for Bone Augmentation Using Intraoral Autogenous Bone Blocks

Multitier Technique for Bone Augmentation Using Intraoral Autogenous Bone Blocks
Brånemarket al1 originally described autologous bone grafts used with dental implants,and they are now a well-accepted procedure in oral and maxillofacial rehabilitation. Placement of an end osseous implant requires sufficient bone volume for complete bone coverage.Further-more,the patter no fridge resorption ,which contributes to a nun favorable maxillo mandibular relationship,requires angulation of the implant and/or angled abutment,and affects the proximity of adjacent facial concavities (maxillary sinus,nasal cavity)and vital structures(mandibular nerve).

Author(s): Devorah Schwartz-Arad, DMD, PhD;Liran Levin, DMD
View Article>>
Influence of Thin Mucosal Tissues on Crestal Bone Stability Around Implants With Platform Switching: A 1-year Pilot Study

Influence of Thin Mucosal Tissues on Crestal Bone Stability Around Implants With Platform Switching: A 1-year Pilot Study
The aim of this pilot study was to determine what effect thin mucosal tissues can have on crestal bone stability around implants with platform switching. Within the limitations of this pilot study it can be concluded that implants with platform switching did not preserve crestal bone better in comparison with implants with traditional implant-abutment connection if, at the time of implant placement, thin mucosal tissues were present.

Author(s): Tomas Linkevicius, DDS, Dip Pros, PhD;Peteris Apse, Prof, DDS, Dip Pros, MSc (Toronto); Dr hab Med (Latvia); Simonas Grybauskas, DDS, MOS, RCSEd, PhD; Algirdas Puisys, DDS
View Article>>
Contact Us | Privacy Policy | Terms of Use
©2014

Preferred Language: English Flag
Contact Us · Login · Register