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Video Details
PRGF— Plasma Rich in Growth Factors: A Simple Solution for Implant & Regenerative Surgery - Part 1 of 2

Description:
Immediate gratification finds new meaning for the “Baby Boomer” population—those 50+ year-olds who lead busy lives and careers and demand service, luxury, and immediate load implants. This is the same group who wishes to retain their youth and in whom the hands of the healing clock are slowed. Today, the challenge of satisfying their needs and wants becomes simplified with the use of plasma rich in growth factors (PRGF), a gel-like substance prepared from two to four 5-cc vials of the patient’s own blood that have been subjected to a 8-minute centrifugation cycle at 460g, then meticulously pipetted into plasma fractions that contain the growth factors targeted for regeneration of both hard and soft tissue (Figure 1). Of the growth factors (GFs) most abundant in PRGF are 3 whose actions most significantly affect this regenerative process. PDGF increases the proliferation of osteoblasts in vitro; TGF- in specific doses boosts type I and type IV collagen-derived protein synthesis as well as increases mineralization of the bone matrix, favoring implant anchorage. Insulin-like growth factor-I (IGF-I) stimulates bone formation, inducing cellular proliferation, differentiation, and biosynthesis of type I collagen in addition to its mitogenic effect on multinucleated osteoclastic cells.1 More importantly, the unique combination of GFs produced with this protocol works synergistically. PRGF differentiates itself from other platelet-rich plasmas (PRPs) because it intentionally excludes inflammatory leukocytes; moreover, PRGF’s activation with calcium chloride alone forbids the use of thrombin because it shocks platelets. (The use of bovine thrombin is prohibited in Europe.2) Instead, the PRGF activation protocol yields a gradual-release kinetics for precious healing proteins stored in the alpha-granules. Current treatment protocols recommend a routine 6-12 month course of healing; this requirement increases the risk of reabsorption of the alveolar process and loss of crestal height and width that, in some cases, can delay, jeopardize, or even preclude implant placement. Others work reasonably well on soft tissue regeneration but fail with bone regeneration.4,5 Intervention with PRGF in the same surgery as the extraction can derail the physiological inevitability of further crestal bone loss and improve the quality and quantity of bone regenerated. Such a scenario is possible thanks to the PRGF technique, which dramatically hastens the healing process in post-extraction sites, as well as grafting for peri-apical lesions, 3-wall defects, large craters around teeth, gingival recession and, in some cases, can enable immediate implant placement which would have been delayed otherwise.6-10 Another favorable clinical observation is that over 10 years in 5,000 post-extraction sites filled with PRGF in this practice, there has not been even one incident of alveolitis (dry socket).

Date Added:
10/28/2013

Author(s):

Eduardo Anitua, MD, DDS, PhD Eduardo Anitua, MD, DDS, PhD
Eduardo Anitua received M.D. in medicine and surgery at the University of Salamanca. He is specialist in Stomatology by the University of the Basque Country (Bilbao, Spain), c...
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Questions & Comments
ismail salejee - (12/8/2013 7:24 AM)

DR ANITUA thank you, with deep appreciation , for your excellent and comprehensive review for the groundbreaking use of prgf for dental and medical applications.Moreover , the dental community is indebted for your many years of pioneering work to develop this concept to its current level.I am keenly awaiting part 2!Once again,your efforts are noted and valued . ismail south africa

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