Dental Education
Online Dental Education Dental education lectures and videos Online dental ce Dental education articles Expert dental educators Dental products education Dental Community
 
Video Details
PRGF— Plasma Rich in Growth Factors: A Simple Solution for Implant & Regenerative Surgery - Part 1 of 2

Description:
Immediate gratification finds new meaning for the “Baby Boomer” population—those 50+ year-olds who lead busy lives and careers and demand service, luxury, and immediate load implants. This is the same group who wishes to retain their youth and in whom the hands of the healing clock are slowed. Today, the challenge of satisfying their needs and wants becomes simplified with the use of plasma rich in growth factors (PRGF), a gel-like substance prepared from two to four 5-cc vials of the patient’s own blood that have been subjected to a 8-minute centrifugation cycle at 460g, then meticulously pipetted into plasma fractions that contain the growth factors targeted for regeneration of both hard and soft tissue (Figure 1). Of the growth factors (GFs) most abundant in PRGF are 3 whose actions most significantly affect this regenerative process. PDGF increases the proliferation of osteoblasts in vitro; TGF- in specific doses boosts type I and type IV collagen-derived protein synthesis as well as increases mineralization of the bone matrix, favoring implant anchorage. Insulin-like growth factor-I (IGF-I) stimulates bone formation, inducing cellular proliferation, differentiation, and biosynthesis of type I collagen in addition to its mitogenic effect on multinucleated osteoclastic cells.1 More importantly, the unique combination of GFs produced with this protocol works synergistically. PRGF differentiates itself from other platelet-rich plasmas (PRPs) because it intentionally excludes inflammatory leukocytes; moreover, PRGF’s activation with calcium chloride alone forbids the use of thrombin because it shocks platelets. (The use of bovine thrombin is prohibited in Europe.2) Instead, the PRGF activation protocol yields a gradual-release kinetics for precious healing proteins stored in the alpha-granules. Current treatment protocols recommend a routine 6-12 month course of healing; this requirement increases the risk of reabsorption of the alveolar process and loss of crestal height and width that, in some cases, can delay, jeopardize, or even preclude implant placement. Others work reasonably well on soft tissue regeneration but fail with bone regeneration.4,5 Intervention with PRGF in the same surgery as the extraction can derail the physiological inevitability of further crestal bone loss and improve the quality and quantity of bone regenerated. Such a scenario is possible thanks to the PRGF technique, which dramatically hastens the healing process in post-extraction sites, as well as grafting for peri-apical lesions, 3-wall defects, large craters around teeth, gingival recession and, in some cases, can enable immediate implant placement which would have been delayed otherwise.6-10 Another favorable clinical observation is that over 10 years in 5,000 post-extraction sites filled with PRGF in this practice, there has not been even one incident of alveolitis (dry socket).

Date Added:
10/28/2013

Author(s):

Eduardo Anitua, MD, DDS, PhD Eduardo Anitua, MD, DDS, PhD
Eduardo Anitua received M.D. in medicine and surgery at the University of Salamanca. He is specialist in Stomatology by the University of the Basque Country (Bilbao, Spain), c...
[read more]


Featured Products
B.T.I. Biotechnology Institute
PRGF Endoret



Questions & Comments
ismail salejee - (12/8/2013 7:24 AM)

DR ANITUA thank you, with deep appreciation , for your excellent and comprehensive review for the groundbreaking use of prgf for dental and medical applications.Moreover , the dental community is indebted for your many years of pioneering work to develop this concept to its current level.I am keenly awaiting part 2!Once again,your efforts are noted and valued . ismail south africa

Related Videos
Growth Factor Mediated Regenerative Therapies Premium Member Content

Growth Factor Mediated Regenerative Therapies
In this very technical and scientific presentation, Dr. Joseph Choukroun, a physician and researcher from France, describes the benefits of Platelet Rich Fibrin (PRF) in wound healing. He emphasizes the effect of PRF on the two essential factors of wound healing which are new vessels and cells in surgical sites like extraction sockets, sinus augmentation and more.

Presented By: Joseph Choukroun, MD
Presentation Style: Video
Community Rating:
 
Watch Now>>
Innovative Technique for Ridge Augmentation Using SonicWeld RX Rigid Resorbable Barrier System - Part 3 of 5 Premium Member Content

Innovative Technique for Ridge Augmentation Using SonicWeld RX Rigid Resorbable Barrier System - Part 3 of 5
Dr. Gerhard Iglhaut describes the science as well as the step-by-step techniques for utilizing an innovative new resorbable rigid membrane and fixation system for ridge augmentation.

Presented By: Gerhard Michael Iglhaut, DDS
Presentation Style: Lecture
Community Rating:
 
Watch Now>>
Ridge Preservation and Augmentation In Immediate Implant Therapy Part 2 Premium Member Content

Ridge Preservation and Augmentation In Immediate Implant Therapy Part 2
Dr. Horowitz utilizes clinical cases and research to outline successful approaches to extraction site enhancement and implant placement.

Presented By: Robert A. Horowitz, DDS
Presentation Style: Lecture
Community Rating:
 
Watch Now>>
Related Courses
Osseointegration & Augmentation Premium Member Content

Osseointegration & Augmentation
A 4 part course worth 1 CEU.

Presented By: Maurice Salama, DMD;Ziv Mazor, DMD;Hom-Lay Wang, DDS, MSD, PhD;Ady Palti, DDS
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
BMP, PRP, PRGF and PRF; At the Edge of Regenerative Surgery Premium Member Content

BMP, PRP, PRGF and PRF; At the Edge of Regenerative Surgery
This webinar will review the wound healing process and the role that growth factors play in regeneration. BMP, PRP, PRF and PRGF will be reviewed and their clinical applications will be demonstrated.

Presented By: Avi Schetritt, DMD
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
Gaining Horizontal and Vertical Bone with Mineralized Bone Particulate, rh-BMP2 and Resorbable Ultrasonic-Applied Rigid Barriers Premium Member Content

Gaining Horizontal and Vertical Bone with Mineralized Bone Particulate, rh-BMP2 and Resorbable Ultrasonic-Applied Rigid Barriers
The use of titanium mesh has been well described, but so has the complications of removal and exposure. Bioresorbable barriers are now available which can be molded into any desired three-dimensional form, creating a rigid and resorbable construct that is secured to to the bone using ultrasonic energy. This unique solution has been successfully used to create the proper environment for both large lateral and vertical ridge augmentations for situations previously only treated with block grafting or distraction. Dr. Cummings will share his experience as well as the key soft tissue techniques that are critical for the success of any large augmentation.

Presented By: Lewis C. Cummings, DDS, MS
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
Related Articles
Minimally Invasive Alveolar Ridge Augmentation Procedure (Tunneling Technique) Using rhPDGF-BB in Combination with Three Matrices: A Case Series

Minimally Invasive Alveolar Ridge Augmentation Procedure (Tunneling Technique) Using rhPDGF-BB in Combination with Three Matrices: A Case Series
This study investigated a minimally invasive surgical procedure for alveolar ridge augmentation that combined recombinant human platelet-derived growth factor BB (rhPDGF-BB) and three different matrices.

Author(s): Myron Nevins, DDS;Marc L. Nevins, DMD, MMSc; Marcelo Camelo, DDS; Peter Schupbach, PhD; Bernard Friedland, BChD, MSc, JD; Joao Marcelo Borges Camelo, DDS; David M. Kim, DDS, DMSc
View Article>>
Physical And Chemical Properties Of Commercially Available Mineralized Bone Allograft

Physical And Chemical Properties Of Commercially Available Mineralized Bone Allograft
Bone graft materials are critical to the success of dental implants when there is a need to increase the volume of bone in a defect. The surface properties of these graft materials will have a profound impact on the outcome of the graft procedure. The clinician has many choices of bone graft substitutes when augmenting bony deficits. Allograft bone is the most widely used class of bone graft substitutes. Within this class there are a number of different bone allografts, which are manufactured utilizing widely varying processing techniques. There also appears to be a wide range of results in the published literature across the spectrum of different bone allografts. This in-vitro study evaluated chemical and surface properties of five different commercially available mineralized bone allografts.

Author(s): David C. Greenspan, Ph.D.
View Article>>
Socket Augmentation: Rationale and Technique

Socket Augmentation: Rationale and Technique
This article presents the rationale behind socket augmentation for future implant placement and describes a technique that has shown to not only facilitate tooth extraction with minimal damage to the surrounding anatomic structures, but also to improve alveolar bone quality and quantity.

Author(s): Hom-Lay Wang, DDS, MSD, PhD;Koichi Kiyonobu, DDS, PhD; Rodrigo F. Neiva, DDS
View Article>>
Contact Us | Privacy Policy | Terms of Use
©2014

Preferred Language: English Flag
Contact Us · Login · Register