Dental Education
Online Dental Education Dental education lectures and videos Online dental ce Dental education articles Expert dental educators Dental products education Dental Community
 
Video Details
PRGF— Plasma Rich in Growth Factors: A Simple Solution for Implant & Regenerative Surgery - Part 1 of 2

Description:
Immediate gratification finds new meaning for the “Baby Boomer” population—those 50+ year-olds who lead busy lives and careers and demand service, luxury, and immediate load implants. This is the same group who wishes to retain their youth and in whom the hands of the healing clock are slowed. Today, the challenge of satisfying their needs and wants becomes simplified with the use of plasma rich in growth factors (PRGF), a gel-like substance prepared from two to four 5-cc vials of the patient’s own blood that have been subjected to a 8-minute centrifugation cycle at 460g, then meticulously pipetted into plasma fractions that contain the growth factors targeted for regeneration of both hard and soft tissue (Figure 1). Of the growth factors (GFs) most abundant in PRGF are 3 whose actions most significantly affect this regenerative process. PDGF increases the proliferation of osteoblasts in vitro; TGF- in specific doses boosts type I and type IV collagen-derived protein synthesis as well as increases mineralization of the bone matrix, favoring implant anchorage. Insulin-like growth factor-I (IGF-I) stimulates bone formation, inducing cellular proliferation, differentiation, and biosynthesis of type I collagen in addition to its mitogenic effect on multinucleated osteoclastic cells.1 More importantly, the unique combination of GFs produced with this protocol works synergistically. PRGF differentiates itself from other platelet-rich plasmas (PRPs) because it intentionally excludes inflammatory leukocytes; moreover, PRGF’s activation with calcium chloride alone forbids the use of thrombin because it shocks platelets. (The use of bovine thrombin is prohibited in Europe.2) Instead, the PRGF activation protocol yields a gradual-release kinetics for precious healing proteins stored in the alpha-granules. Current treatment protocols recommend a routine 6-12 month course of healing; this requirement increases the risk of reabsorption of the alveolar process and loss of crestal height and width that, in some cases, can delay, jeopardize, or even preclude implant placement. Others work reasonably well on soft tissue regeneration but fail with bone regeneration.4,5 Intervention with PRGF in the same surgery as the extraction can derail the physiological inevitability of further crestal bone loss and improve the quality and quantity of bone regenerated. Such a scenario is possible thanks to the PRGF technique, which dramatically hastens the healing process in post-extraction sites, as well as grafting for peri-apical lesions, 3-wall defects, large craters around teeth, gingival recession and, in some cases, can enable immediate implant placement which would have been delayed otherwise.6-10 Another favorable clinical observation is that over 10 years in 5,000 post-extraction sites filled with PRGF in this practice, there has not been even one incident of alveolitis (dry socket).

Date Added:
10/28/2013

Author(s):

Eduardo Anitua, MD, DDS, PhD Eduardo Anitua, MD, DDS, PhD
Eduardo Anitua received M.D. in medicine and surgery at the University of Salamanca. He is specialist in Stomatology by the University of the Basque Country (Bilbao, Spain), c...
[read more]


Featured Products
B.T.I. Biotechnology Institute
PRGF Endoret





Questions & Comments
ismail salejee - (12/8/2013 7:24 AM)

DR ANITUA thank you, with deep appreciation , for your excellent and comprehensive review for the groundbreaking use of prgf for dental and medical applications.Moreover , the dental community is indebted for your many years of pioneering work to develop this concept to its current level.I am keenly awaiting part 2!Once again,your efforts are noted and valued . ismail south africa

Related Videos
Titanium Mesh GBR in Combination with Bioactive Modifiers and Implant Placement Premium Member Content

Titanium Mesh GBR in Combination with Bioactive Modifiers and Implant Placement
This Surgical Video will highlight the utilization of a new CTi Titanium Mesh product that intimately connects to the top of the implant to create space for Guided Bone Regeneration.

Presented By:: Maurice Salama, DMD
Presentation Style: Video
Community Rating:
 
Watch Now>>
Guided Bone Regeneration of a Compromised Extraction Site Premium Member Content

Guided Bone Regeneration of a Compromised Extraction Site
Dr. Michael Sonick shares a routine clinical challenge and demonstrates the extraction of a fractured premolar with simultaneous guided bone regeneration.

Presented By:: Michael Sonick, DMD
Presentation Style: Video
Community Rating:
 
Watch Now>>
Bone Putties for GBR and Ridge Augmentation: A review for the general practitioner - Part 2 of 2 Premium Member Content

Bone Putties for GBR and Ridge Augmentation: A review for the general practitioner - Part 2 of 2
Dr. Michael Tischler reviews the utilization of bone allografts in putty form for guided bone regeneration, GBR, and ridge augmentation.

Presented By:: Michael Tischler, DDS, FAGD
Presentation Style: Video
Community Rating:
 
Watch Now>>
Related Courses
Modern Approach of Full Arch Immediate Loading Premium Member Content

Modern Approach of Full Arch Immediate Loading
In Immediate loading, the survival rate is often based on the follow-up of the osseointegration, but without aesthetic appreciation... The main goal is to achieve osseointegration and aesthetics in order to get long term stability. For this goal we need to obtain both, bone formation and gum thickness, as any failure in one of the 2 factors, will induce the loss of the second factor. This presentation will show my statistics about more than 1100 full arch loaded immediately since 14 years (> 7700 implants)

Presented By:: Alain Simonpieri, DDS
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
BMP, PRP, PRGF and PRF; At the Edge of Regenerative Surgery Premium Member Content

BMP, PRP, PRGF and PRF; At the Edge of Regenerative Surgery
This webinar will review the wound healing process and the role that growth factors play in regeneration. BMP, PRP, PRF and PRGF will be reviewed and their clinical applications will be demonstrated.

Presented By:: Avi Schetritt, DMD
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
Challenges & Management of Peri-Implant Pink Esthetics in Anterior Implant Therapy Premium Member Content

Challenges & Management of Peri-Implant Pink Esthetics in Anterior Implant Therapy
This presentation will highlight different clinical scenarios in which the lack of hard and soft tissue volume may pose difficulties in achieving ideal peri-implant esthetics, in addition to available clinical strategies on how to manage and minimize hard and soft tissue deficiencies when dealing with implant therapy in the esthetic zone.

Presented By:: Sherif Yousri Said, BDS
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
Related Articles
A Bovine-Bone Mineral Block for the Treatment of Severe Ridge Deficiencies in the Anterior Region: A Clinical Case Report

A Bovine-Bone Mineral Block for the Treatment of Severe Ridge Deficiencies in the Anterior Region: A Clinical Case Report
A bovine-bone mineral block was used to treat a severe horizontal and vertical anterior ridge deficiency. Such a block can be shaped to conform to the defect, and it avoids the need for harvesting autogenous bone or fixation of the block with screws.

Author(s): Marius Steigmann, DDS
View Article>>
Mandibular Block Autografts for Alveolar Ridge Augmentation

Mandibular Block Autografts for Alveolar Ridge Augmentation
This article reviews indications, limitations, presurgical evaluation, surgical protocol, and complications associated with mandibular block autografts harvested from the symphysis and ramus buccal shelf for alveolar ridge augmentation. The author draws from 14 years of experience with more than 500 mandibular block autografts.

Author(s): Michael A Pikos, DDS
View Article>>
Guided Bone Regeneration Using a Titanium Membrane at Implant Placement: A Case Report and Literature Discussion

Guided Bone Regeneration Using a Titanium Membrane at Implant Placement: A Case Report and Literature Discussion
Reconstruction of the oral supporting tissues lost by disease or trauma is essential to tooth replacement with dental implant therapy. This treatment requires evidence based augmentative procedures combined with up-to-date and current techniques. Guided bone regeneration (GBR) aims to initialize this process of alveolar ridge reconstruction by utilizing biologically active and supportive materials best coupled to the body’s healing processes. The use of nonresorbable, titanium membranes can achieve GBR by ensuring graft stability and space maintenance so as to ensure optimal neovascularization. Hereafter is a case report of a ridge defect reconstructed at implant placement, with the rationale and current, evidence-based literature discussed.

Author(s): Howard Gluckman, BDS, MChD;Jonathan Du Toit
View Article>>
Contact Us | Privacy Policy | Terms of Use
©2017

Preferred Language: English Flag
Contact Us · Login · Register