Dental Education
Online Dental Education Dental education lectures and videos Online dental ce Dental education articles Expert dental educators Dental products education Dental Community
 
Video Details
PRGF— Plasma Rich in Growth Factors: A Simple Solution for Implant & Regenerative Surgery - Part 1 of 2

Description:
Immediate gratification finds new meaning for the “Baby Boomer” population—those 50+ year-olds who lead busy lives and careers and demand service, luxury, and immediate load implants. This is the same group who wishes to retain their youth and in whom the hands of the healing clock are slowed. Today, the challenge of satisfying their needs and wants becomes simplified with the use of plasma rich in growth factors (PRGF), a gel-like substance prepared from two to four 5-cc vials of the patient’s own blood that have been subjected to a 8-minute centrifugation cycle at 460g, then meticulously pipetted into plasma fractions that contain the growth factors targeted for regeneration of both hard and soft tissue (Figure 1). Of the growth factors (GFs) most abundant in PRGF are 3 whose actions most significantly affect this regenerative process. PDGF increases the proliferation of osteoblasts in vitro; TGF- in specific doses boosts type I and type IV collagen-derived protein synthesis as well as increases mineralization of the bone matrix, favoring implant anchorage. Insulin-like growth factor-I (IGF-I) stimulates bone formation, inducing cellular proliferation, differentiation, and biosynthesis of type I collagen in addition to its mitogenic effect on multinucleated osteoclastic cells.1 More importantly, the unique combination of GFs produced with this protocol works synergistically. PRGF differentiates itself from other platelet-rich plasmas (PRPs) because it intentionally excludes inflammatory leukocytes; moreover, PRGF’s activation with calcium chloride alone forbids the use of thrombin because it shocks platelets. (The use of bovine thrombin is prohibited in Europe.2) Instead, the PRGF activation protocol yields a gradual-release kinetics for precious healing proteins stored in the alpha-granules. Current treatment protocols recommend a routine 6-12 month course of healing; this requirement increases the risk of reabsorption of the alveolar process and loss of crestal height and width that, in some cases, can delay, jeopardize, or even preclude implant placement. Others work reasonably well on soft tissue regeneration but fail with bone regeneration.4,5 Intervention with PRGF in the same surgery as the extraction can derail the physiological inevitability of further crestal bone loss and improve the quality and quantity of bone regenerated. Such a scenario is possible thanks to the PRGF technique, which dramatically hastens the healing process in post-extraction sites, as well as grafting for peri-apical lesions, 3-wall defects, large craters around teeth, gingival recession and, in some cases, can enable immediate implant placement which would have been delayed otherwise.6-10 Another favorable clinical observation is that over 10 years in 5,000 post-extraction sites filled with PRGF in this practice, there has not been even one incident of alveolitis (dry socket).

Date Added:
10/28/2013

Author(s):

Eduardo Anitua, MD, DDS, PhD Eduardo Anitua, MD, DDS, PhD
Eduardo Anitua received M.D. in medicine and surgery at the University of Salamanca. He is specialist in Stomatology by the University of the Basque Country (Bilbao, Spain), c...
[read more]


Featured Products
B.T.I. Biotechnology Institute
PRGF Endoret



Questions & Comments
ismail salejee - (12/8/2013 7:24 AM)

DR ANITUA thank you, with deep appreciation , for your excellent and comprehensive review for the groundbreaking use of prgf for dental and medical applications.Moreover , the dental community is indebted for your many years of pioneering work to develop this concept to its current level.I am keenly awaiting part 2!Once again,your efforts are noted and valued . ismail south africa

Related Videos
Management of Extremely Compromised Bone Grafting Cases: Part 1 Premium Member Content

Management of Extremely Compromised Bone Grafting Cases: Part 1
Dr. Deshpande discusses advanced grafting for the severely atrophied jaw.

Presented By:: Dr. Dilip Deshpande
Presentation Style: Lecture
Community Rating:
 
Watch Now>>
Partners in Synergy - The Webinar Event Augmentation Strategies in Implant Dentistry - Part 1 Premium Member Content

Partners in Synergy - The Webinar Event Augmentation Strategies in Implant Dentistry - Part 1
This lecture will highlight the current available regenerative techniques and protocols to maximize the esthetic results of tooth replacement therapy.

Presented By:: Maurice Salama, DMD;Michael A Pikos, DDS
Presentation Style: Lecture
Community Rating:
 
Watch Now>>
Chin Bone Block Augmentation	Premium Member Content

Chin Bone Block Augmentation
3D CT Technology & Piezosurgical Techniques

Presented By:: Maurice Salama, DMD
Presentation Style: Video
Community Rating:
 
Watch Now>>
Related Courses
Esthetic Zone Reconstruction: Synergy of Hard and Soft Tissue Grafting Premium Member Content

Esthetic Zone Reconstruction: Synergy of Hard and Soft Tissue Grafting
The loss of alveolar ridge contour in the esthetic zone compromises both esthetics and function. This clinical presentation will focus on the application of both hard and soft tissue grafting in the esthetic zone implementing state of the art interactive CT diagnosis and treatment planning for optimal esthetic implant reconstruction. Emphasis will be on indications, graft and harvest site assessment, timing, and use of bioactive modifiers including BMP, PRGF and PDGF. The surgical protocol utilizing allogeneic and autogenous grafts in conjunction with connective tissue grafts, acellular dermis matrix, and related soft tissue procedures to avoid functional and esthetic pitfalls will be featured. Pre and post-grafting prosthetic workup, interactive CT graft assessment and perio prosthetic driven implant planning, stent driven implant placement, and computer milled abutment fabrication including guided surgery will be included.

Presented By:: Michael A Pikos, DDS
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
BMP, PRP, PRGF and PRF; At the Edge of Regenerative Surgery Premium Member Content

BMP, PRP, PRGF and PRF; At the Edge of Regenerative Surgery
This webinar will review the wound healing process and the role that growth factors play in regeneration. BMP, PRP, PRF and PRGF will be reviewed and their clinical applications will be demonstrated.

Presented By:: Avi Schetritt, DMD
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
Managing the Extraction Site - Optimal Preservation and Enhancement Techniques Premium Member Content

Managing the Extraction Site - Optimal Preservation and Enhancement Techniques
The importance of piezosurgery, atraumatic surgical technique, the use of bone grafts, resorbable membranes and growth factors will be elucidated along with soft tissue enhancement.

Presented By:: Michael Sonick, DMD
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
Related Articles
Maximizing Aesthetics in the Deficient Alveolar Ridge

Maximizing Aesthetics in the Deficient Alveolar Ridge
This article will present a predictable method for replacing the lost bone prior to implant placement through the ramus block graft technique.

Author(s): Steven L. Rasner, DMD, MAGD
View Article>>
Use of PRGF to Accelerate Bone and Soft Tissue Regeneration in Postextraction Sites

Use of PRGF to Accelerate Bone and Soft Tissue Regeneration in Postextraction Sites
Evealuation of regenerated bone density.

Author(s): Eduardo Anitua, MD, DDS, PhD;Gorka Orive, MD, DDS; Isabel Andia, PhD
View Article>>
Peri-Implant Tissue Response Following Connective Tissue and Bone Grafting in Conjunction with Immediate Single-Tooth Replacement in the Esthetic Zone

Peri-Implant Tissue Response Following Connective Tissue and Bone Grafting in Conjunction with Immediate Single-Tooth Replacement in the Esthetic Zone
The case series evaluated the peri-implant tissue response following extraction and immediate placement and restoration of an implant in conjunction with subepithelial connective tissue graft (SCTG) and bone grafting in the esthetic zone.

Author(s): Hirotaka Tsuda, DDS; Kitichai Rungcharassaeng, DDS, MS; Joseph Y. K. Kan, DDS, MS; Phillip Roe, DDS, MS; Jaime L. Lozada, DDS; Grenith Zimmerman, PhD
View Article>>
Contact Us | Privacy Policy | Terms of Use
©2014

Preferred Language: English Flag
Contact Us · Login · Register