Dental Education
Online Dental Education Dental education lectures and videos Online dental ce Dental education articles Expert dental educators Dental products education Dental Community
 
Video Details
PRGF— Plasma Rich in Growth Factors: A Simple Solution for Implant & Regenerative Surgery - Part 1 of 2

Description:
Immediate gratification finds new meaning for the “Baby Boomer” population—those 50+ year-olds who lead busy lives and careers and demand service, luxury, and immediate load implants. This is the same group who wishes to retain their youth and in whom the hands of the healing clock are slowed. Today, the challenge of satisfying their needs and wants becomes simplified with the use of plasma rich in growth factors (PRGF), a gel-like substance prepared from two to four 5-cc vials of the patient’s own blood that have been subjected to a 8-minute centrifugation cycle at 460g, then meticulously pipetted into plasma fractions that contain the growth factors targeted for regeneration of both hard and soft tissue (Figure 1). Of the growth factors (GFs) most abundant in PRGF are 3 whose actions most significantly affect this regenerative process. PDGF increases the proliferation of osteoblasts in vitro; TGF- in specific doses boosts type I and type IV collagen-derived protein synthesis as well as increases mineralization of the bone matrix, favoring implant anchorage. Insulin-like growth factor-I (IGF-I) stimulates bone formation, inducing cellular proliferation, differentiation, and biosynthesis of type I collagen in addition to its mitogenic effect on multinucleated osteoclastic cells.1 More importantly, the unique combination of GFs produced with this protocol works synergistically. PRGF differentiates itself from other platelet-rich plasmas (PRPs) because it intentionally excludes inflammatory leukocytes; moreover, PRGF’s activation with calcium chloride alone forbids the use of thrombin because it shocks platelets. (The use of bovine thrombin is prohibited in Europe.2) Instead, the PRGF activation protocol yields a gradual-release kinetics for precious healing proteins stored in the alpha-granules. Current treatment protocols recommend a routine 6-12 month course of healing; this requirement increases the risk of reabsorption of the alveolar process and loss of crestal height and width that, in some cases, can delay, jeopardize, or even preclude implant placement. Others work reasonably well on soft tissue regeneration but fail with bone regeneration.4,5 Intervention with PRGF in the same surgery as the extraction can derail the physiological inevitability of further crestal bone loss and improve the quality and quantity of bone regenerated. Such a scenario is possible thanks to the PRGF technique, which dramatically hastens the healing process in post-extraction sites, as well as grafting for peri-apical lesions, 3-wall defects, large craters around teeth, gingival recession and, in some cases, can enable immediate implant placement which would have been delayed otherwise.6-10 Another favorable clinical observation is that over 10 years in 5,000 post-extraction sites filled with PRGF in this practice, there has not been even one incident of alveolitis (dry socket).

Date Added:
10/28/2013

Author(s):

Eduardo Anitua, MD, DDS, PhD Eduardo Anitua, MD, DDS, PhD
Eduardo Anitua received M.D. in medicine and surgery at the University of Salamanca. He is specialist in Stomatology by the University of the Basque Country (Bilbao, Spain), c...
[read more]


Featured Products
B.T.I. Biotechnology Institute
PRGF Endoret



Questions & Comments
ismail salejee - (12/8/2013 7:24 AM)

DR ANITUA thank you, with deep appreciation , for your excellent and comprehensive review for the groundbreaking use of prgf for dental and medical applications.Moreover , the dental community is indebted for your many years of pioneering work to develop this concept to its current level.I am keenly awaiting part 2!Once again,your efforts are noted and valued . ismail south africa

Related Videos
Management of Extremely Compromised Bone Grafting Cases: Part 3 Premium Member Content

Management of Extremely Compromised Bone Grafting Cases: Part 3
Dr. Deshpande discusses advanced grafting for the severely atrophied jaw.

Presented By:: Dr. Dilip Deshpande
Presentation Style: Lecture
Community Rating:
 
Watch Now>>
Managing the Extraction Site - Optimal Preservation and Enhancement Techniques Premium Member Content

Managing the Extraction Site - Optimal Preservation and Enhancement Techniques
The importance of piezosurgery, atraumatic surgical technique, the use of bone grafts, resorbable membranes and growth factors will be elucidated along with soft tissue enhancement.

Presented By:: Michael Sonick, DMD
Presentation Style: Lecture
Community Rating:
 
Watch Now>>
The Palatal Bone Block - An Innovative Autogenous Harvest Site Premium Member Content

The Palatal Bone Block - An Innovative Autogenous Harvest Site
This lecture will take you through the step by step technique of harvesting and fixing the bone blocks harvested from the palate.

Presented By:: Howard Gluckman, BDS, MChD
Presentation Style: Lecture
Community Rating:
 
Watch Now>>
Related Courses
Managing the Extraction Site - Optimal Preservation and Enhancement Techniques Premium Member Content

Managing the Extraction Site - Optimal Preservation and Enhancement Techniques
The importance of piezosurgery, atraumatic surgical technique, the use of bone grafts, resorbable membranes and growth factors will be elucidated along with soft tissue enhancement.

Presented By:: Michael Sonick, DMD
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
Osseointegration & Augmentation Premium Member Content

Osseointegration & Augmentation
A 4 part course worth 1 CEU.

Presented By:: Maurice Salama, DMD;Ziv Mazor, DMD;Hom-Lay Wang, DDS, MSD, PhD;Ady Palti, DDS
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
Creative Next Generation Surgical Tools and Solutions for the Implant Practice Premium Member Content

Creative Next Generation Surgical Tools and Solutions for the Implant Practice
Modern Bone Grafting has become more predictable than ever before. Recent developments in CBCT 3D Diagnosis and the utilization of bioactive modifiers such as PRGF, PRF and BMP-2 have stimulated further advances in surgical techniques as well as a New Age Surgical Armamentarium to maximize the efficiencies and success of these sophisticated procedures.

Presented By:: Maurice Salama, DMD
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
Related Articles
Periosteal Pocket Flap for Horizontal Bone Regeneration: A Case Series

Periosteal Pocket Flap for Horizontal Bone Regeneration: A Case Series
This article describes a buccal periosteal pocket flap proposed to overcome these challenges. The flap design results in a periosteal pocket, which allows filling of bone-grafting material while facilitating primary, tension-free soft tissue closure by splitting of the mucosa. The flap gives stability to the augmented volume within the pocket. Ridge width changes of five patients consecutively treated with this technique were recorded before and 24 weeks after augmentation.

Author(s): Marius Steigmann, DDS;Maurice Salama, DMD;Hom-Lay Wang, DDS, MSD, PhD
View Article>>
Long-Term Block Graft Stability in Thin Periodontal Biotype Patients - A Clinical and Tomographic Study

Long-Term Block Graft Stability in Thin Periodontal Biotype Patients - A Clinical and Tomographic Study
Autogenous block grafting seems to be a predictable treatment modality to reconstruct alveolar ridge defects in the long term. A thin periodontal biotype did not seem to affect the volume of transplanted bone for the population studied.

Author(s): Fernando Verdugo, DDS;Krikor Simonian, DDS;Alon Frydman, DDS;Antonio D'Addona, DDS;José Pontón, PhD
View Article>>
Immediate Implant Placement with GBR Using Alloplast

Immediate Implant Placement with GBR Using Alloplast
Presented here is a case report wherein guided bone regeneration was done simultaneously at the time of immediate implant placement to achieve a desirable outcome.

Author(s): Lanka Mahesh, BDS, MBA;Dr. Sagrika Shukla; Dr. Prashant Nanda; Dr. Manoj Eapen
View Article>>
Contact Us | Privacy Policy | Terms of Use
©2015

Preferred Language: English Flag
Contact Us · Login · Register