Dental Education
Online Dental Education Dental education lectures and videos Online dental ce Dental education articles Expert dental educators Dental products education Dental Community
 
Video Details
PRGF— Plasma Rich in Growth Factors: A Simple Solution for Implant & Regenerative Surgery - Part 1 of 2

Description:
Immediate gratification finds new meaning for the “Baby Boomer” population—those 50+ year-olds who lead busy lives and careers and demand service, luxury, and immediate load implants. This is the same group who wishes to retain their youth and in whom the hands of the healing clock are slowed. Today, the challenge of satisfying their needs and wants becomes simplified with the use of plasma rich in growth factors (PRGF), a gel-like substance prepared from two to four 5-cc vials of the patient’s own blood that have been subjected to a 8-minute centrifugation cycle at 460g, then meticulously pipetted into plasma fractions that contain the growth factors targeted for regeneration of both hard and soft tissue (Figure 1). Of the growth factors (GFs) most abundant in PRGF are 3 whose actions most significantly affect this regenerative process. PDGF increases the proliferation of osteoblasts in vitro; TGF- in specific doses boosts type I and type IV collagen-derived protein synthesis as well as increases mineralization of the bone matrix, favoring implant anchorage. Insulin-like growth factor-I (IGF-I) stimulates bone formation, inducing cellular proliferation, differentiation, and biosynthesis of type I collagen in addition to its mitogenic effect on multinucleated osteoclastic cells.1 More importantly, the unique combination of GFs produced with this protocol works synergistically. PRGF differentiates itself from other platelet-rich plasmas (PRPs) because it intentionally excludes inflammatory leukocytes; moreover, PRGF’s activation with calcium chloride alone forbids the use of thrombin because it shocks platelets. (The use of bovine thrombin is prohibited in Europe.2) Instead, the PRGF activation protocol yields a gradual-release kinetics for precious healing proteins stored in the alpha-granules. Current treatment protocols recommend a routine 6-12 month course of healing; this requirement increases the risk of reabsorption of the alveolar process and loss of crestal height and width that, in some cases, can delay, jeopardize, or even preclude implant placement. Others work reasonably well on soft tissue regeneration but fail with bone regeneration.4,5 Intervention with PRGF in the same surgery as the extraction can derail the physiological inevitability of further crestal bone loss and improve the quality and quantity of bone regenerated. Such a scenario is possible thanks to the PRGF technique, which dramatically hastens the healing process in post-extraction sites, as well as grafting for peri-apical lesions, 3-wall defects, large craters around teeth, gingival recession and, in some cases, can enable immediate implant placement which would have been delayed otherwise.6-10 Another favorable clinical observation is that over 10 years in 5,000 post-extraction sites filled with PRGF in this practice, there has not been even one incident of alveolitis (dry socket).

Date Added:
10/28/2013

Author(s):

Eduardo Anitua, MD, DDS, PhD Eduardo Anitua, MD, DDS, PhD
Eduardo Anitua received M.D. in medicine and surgery at the University of Salamanca. He is specialist in Stomatology by the University of the Basque Country (Bilbao, Spain), c...
[read more]


Featured Products
B.T.I. Biotechnology Institute
PRGF Endoret



Questions & Comments
ismail salejee - (12/8/2013 7:24 AM)

DR ANITUA thank you, with deep appreciation , for your excellent and comprehensive review for the groundbreaking use of prgf for dental and medical applications.Moreover , the dental community is indebted for your many years of pioneering work to develop this concept to its current level.I am keenly awaiting part 2!Once again,your efforts are noted and valued . ismail south africa

Related Videos
Severe Atrophic Anterior Maxilla: Advantages of Combined Therapy - Part 1 of 2 Premium Member Content

Severe Atrophic Anterior Maxilla: Advantages of Combined Therapy - Part 1 of 2
Anterior maxillary alveolar bone deficiency, can prevent implant placement for fixed rehabilitation and jeopardize the esthetic outcome. Clinical case of severe atrophy of anterior maxilla, due to loss of implants, is described: A combination of sub-nasal procedure and intra-oral autologous onlay bone graft were used for ridge augmentation and dental implant placement in steps procedure, combined with Bio-Oss saturated in Platelets Rich Plasma (PRP) and covered with platelets-poor-plasma (PPP) as a "biological membrane".

Presented By:: Devorah Schwartz-Arad, DMD, PhD
Presentation Style: Video
Community Rating:
 
Watch Now>>
Surgical Considerations for Sinus Augmentation - Part 2 Premium Member Content

Surgical Considerations for Sinus Augmentation - Part 2
Dr. Michael Pikos continues his demonstration of the step-by-step procedures necessary to perform lateral window sinus augmentation.

Presented By:: Michael A Pikos, DDS
Presentation Style: Video
Community Rating:
 
Watch Now>>
Optimum Implant Esthetics Through Extraction Socket Preservation Techniques. Premium Member Content

Optimum Implant Esthetics Through Extraction Socket Preservation Techniques.
This presentation will focus on ideal implant placement through maintaining the bucco-lingual dimension of bone following extraction through extraction socket preservation techniques.

Presented By:: Mario A. Vilardi, DMD
Presentation Style: Lecture
Community Rating:
 
Watch Now>>
Related Courses
Optimum Implant Esthetics Through Extraction Socket Preservation Techniques Premium Member Content

Optimum Implant Esthetics Through Extraction Socket Preservation Techniques
This presentation will focus on ideal implant placement through maintaining the bucco-lingual dimension of bone following extraction through extraction socket preservation techniques.

Presented By:: Mario A. Vilardi, DMD
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
Partners in Synergy - The Webinar Event; Augmentation Strategies in Implant Dentistry Premium Member Content

Partners in Synergy - The Webinar Event; Augmentation Strategies in Implant Dentistry
This course will highlight the current available regenerative techniques and protocols to maximize the esthetic results of tooth replacement therapy. Extraction site management, labial bone enhancement as well as current gingival augmentation techniques will be featured. These highly acclaimed clinicians and educators will team up to provide a glimpse of their upcoming LIVE Synergy VI conference June 11th - 14th, 2015 in Orlando, Florida.

Presented By:: Maurice Salama, DMD;Michael A Pikos, DDS
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
Extraction and Bone Grafting Techniques to Optimize Site Preservation Premium Member Content

Extraction and Bone Grafting Techniques to Optimize Site Preservation
Implant placement is dependent upon bone quantity and quality. The ideal opportunity for bone preservation exists at the time of tooth extraction. All too often this opportunity is lost. Extraction techniques will be demonstrated that not only preserve but augment the amount of alveolar bone. The importance of piezosurgery, atraumatic surgical technique, the use of bone grafts, resorbable membranes and growth factors will be elucidated.

Presented By:: Michael Sonick, DMD
Presentation Style: Online Course
CE Hours: 1 CEU (Continuing Education Unit)
Watch Now>>
Related Articles
Bone Augmentation of the Atrophic Posterior Mandible for Dental Implants Using rhBMP-2 and Titanium Mesh: Clinical Technique and Early Results

Bone Augmentation of the Atrophic Posterior Mandible for Dental Implants Using rhBMP-2 and Titanium Mesh: Clinical Technique and Early Results
The purpose of the case series was to evaluate the use of recombinant human bone morphogenetic protein 2/acelluar collagen sponge (rhBMP-2/ACS) and titanium mesh for augmentation of the atrophic posterior mandible prior to implant insertion.

Author(s): Craig M Misch, DDS, MDS
View Article>>
A Fixed Whole-Mouth Rehabilitation Utilizing Natural Abutments and Implants: Treatment Concepts and Clinical Realization

A Fixed Whole-Mouth Rehabilitation Utilizing Natural Abutments and Implants: Treatment Concepts and Clinical Realization
A 45-year-old female patient presented to the clinic with a request to treat her deteriorating dentition that had been reconstructed 15 years ago with fixed restorations. Clinical examination revealed fixed partial dentures cemented to natural abutments in the maxilla, whereas telescopic restorations were cemented to natural abutments bilaterally in the mandible. The treatment plan included a whole-mouth rehabilitation utilizing natural teeth and implants. As the patient declined any surgical augmentation…

Author(s): Nitzan Bichacho, DMD;Rafi Lahav, MDT, Cobi J. Landsberg, DMD
View Article>>
Immediate Implant Placement into Extraction Sockets with Labial Plate Dehiscence Defects: A Clinical Case Series

Immediate Implant Placement into Extraction Sockets with Labial Plate Dehiscence Defects: A Clinical Case Series
To measure the buccal plate reconstruction of extraction sockets with labial plate dehiscence defects using a bone allograft in combination with an absorbable collagen membrane and a custom-healing abutment at the time of tooth removal. Implants placed into sockets with labial plate dehiscence defects demonstrated radiographic reformation of the labial plate dehiscence defect at 6 to 9 months post-treatment. The net gain in labial plate on CBCT in L1 and L2 was 3.0 mm, where 0 mm existed at pre-treatment. The minimum amount of labial plate thickness of 2.0 mm was achieved in all treated sites, evaluated radiographically at 6-9 months post-operatively, in a single procedure, without flap elevation and maintaining the gingival architecture and satisfactory esthetics.

Author(s): Stephen J. Chu, DMD, MSD, CDT;Dennis P. Tarnow, DDS;Guido O. Sarnachiaro, DDS; Evangelina Sarnachiaro, DDS; Sergio Luis Gotta, DDS
View Article>>
Contact Us | Privacy Policy | Terms of Use
©2016

Preferred Language: English Flag
Contact Us · Login · Register