Platelet Rich Fibrin (L-PRF) is an autologous fibrin mesh made by spinning down whole blood and harvesting the platelet and leukocyte containing fibrin fraction.

It is a non-thrombinized autologous graft material that releases growth factors over an extended period of time. Having the platelets within a non-thrombinized fibrin mesh, along with leukocytes, releases PDGF, VEGF, TGFb, and thrombospondin over 7-14 days, precisely when angiogenesis is peaking and bone growth begins.

PRP requires the use of thrombin to help release growth factors from alpha granules within the platelets. This sudden release of cytokines is available for approximately 7-14 hours. After that, the effect of these growth factors dramatically diminishes.

PRF is superior to PRP and PRGF because there is actually an INCREASE in cytokine release at the most important time during wound healing.

PRF is used to fabricate autologous membranes that can be sutured in place and will increase the biotype of tissue. It can also be used to fabricate plugs for extraction sites and in extraction/immediate implant sites to graft the space between implant and facial plate as an alternative to bone grafting.