Course:

The Time/Concentration Curve for Incremental Oral Administration differs from that of the Single-Dose Protocols in that additional sedative medication doses are given incrementally (“Dosing To Effect” – Not Titration*) to keep the patient at a “steady state” of sedation. This allows for better control of depth and length of sedation while maintaining the lowest total dose of a medication. Remember to use the lowest effective dose of any sedative. Along with the ability to readily extend the depth and length of the sedation, incremental dosing affords the clinician the opportunity to administer smaller doses initially as well as throughout the appointment). This allows for an extra degree of safety not always possible with bolus dosing. In addition, the ability to administer additional doses allows for fewer sedation failures due to the high degree of individual variability.