Article:
Antimicrobial Effect of a Single Dose of Amoxicillin on the Oral Microbiota

Summary:
Amoxicillin is commonly used in oral surgery for antimicrobial prophylaxis against surgical-site infection and
bacteremia because of its effect on oral streptococci. The aim of this study was to determine whether amoxicillin reaches
the break-point concentrations in saliva and has any effect on the salivary microbiota, colonizing bacteria on mucosal
membranes and on the gingival crevice after a single dose of amoxicillin. A single dose given as prophylaxis to prevent a surgical-site infection results in a significant reducing effect on
the oral streptococcal microflora in the gingival crevice and may have an impact on bacteria spreading into tissues and the
bacteria of streptococci.